KT-413 | IRAK4 PROTAC | Probechem Biochemicals

Chemical Structure : KT-413

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KT-413 (KT413)

货号: PC-22767Not For Human Use, Lab Use Only.

KT-413 is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells.

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生物&药学活性

KT-413 is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells.
KT-413 induces the CRBN-mediated degradation of IRAK4, and to recruit and degrade the IMiD neosubstrates Ikaros and Aiolos.
KT-413 displays robust antiproliferative activity with IC50 of 11 nM against DLBCL cancer line OCI-Ly10.
KT-413 (3, 10, and 30 mg/kg, po, qd) causes complete tumor regression in MYD88 mutant ABC DLBCL model.

物理化学性质&存储条件

分子量	871.98
分子式	C45H48F3N7O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((1r,4r)-4-((6-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-2-azaspiro[3.3]heptan-2-yl)methyl)cyclohexyl)-5-(2-hydroxypropan-2-yl)benzo[d]thiazol-6-yl)-6-(trifluoromethyl)picolinamide

参考文献

1. Weiss MM, et al. J Med Chem. 2024 Jul 11;67(13):10548-10566.

KT-413 (KT413)

生物&药学活性

物理化学性质&存储条件

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KT-413 (KT413)

生物&药学活性

物理化学性质&存储条件

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