| Cat. No. |
Product Name |
Information |
| PC-24902 |
SJ46421
BRD3 PROTAC
|
SJ46421 is a specific JQ1-based KLHDC2 PROTAC protein degrader of BRD3, induces selective BRD3 degradation in cells, promotes selective cooperative ternary complex formation with BRD3BD2 with IC50 of 7.8 nM. |
| PC-24888 |
INY-05-040
AKT PROTAC
|
INY-05-040 is a second-generation pan-AKT PROTAC degrader, selectively and rapidly (<5 h) degrades all three AKT isoforms and inhibits downstream signaling and cell proliferation in 288 cancer cell lines. |
| PC-24880 |
dASK1-VHL
ASK1 PROTAC
|
dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1). |
| PC-24813 |
CDK9 degrader AZ-9
CDK9 degrader
|
CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells. |
| PC-24804 |
WZH-17-002
ALK PROTAC
|
WZH-17-002 is a potent, selective ALK PROTAC degrader with DC50 of 25 nM both in H3122 and DFCI076 cells. |
| PC-24767 |
INNO-220
CK1α degrader
|
INNO-220 is a highly selective and potent, CRBN-dependent, orally bioavailable degrader of CK1α without affecting IKZF1/3, impairs cell viability and selectively degraded CK1α in lymphoma cells. |
| PC-24732 |
Aster-A PROTAC NGF3
Aster-A degrader
|
Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells. |
| PC-24675 |
Linker-free PROTAC Pro-DA
BCR-ABL degrader
|
Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM. |
| PC-24674 |
Linker-free PROTAC Pro-BA
EML4-ALK degrader
|
Linker-free PROTAC Pro-BA is a linker-free PROTAC degarder of EML4-ALK protein with DC50 of 74 nM and achieves an 82% reduction at 500 nM in H3122 cells, shows cell growth IC50 of 34 nM. |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4). |
| PC-24663 |
GDC-2992
AR PROTAC
|
GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells. |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
