| Cat. No. |
Product Name |
Information |
| PC-28683 |
HBC-8
MAP3K1 degrader
|
HBC-8 is a potent, selective CRBN-dependent MAP3K1 PROTAC degrader of 200 nM and 45 nM in T47D and NCIH1048, respectively, shows IC50 of 0.25 uM in HCT116 WT cells. |
| PC-28663 |
KT-474 hydrochloride
IRAK4 PROTAC
|
KT-474 hydrochloride (Tipasertideg, SAR444656, KYM-001) is a potent, selective, and orally bioavailable heterobifunctional IRAK4 PROTAC degrader with DC50 of 2 nM in OCI-Ly10 cells, IC50 of 41 nM. |
| PC-28661 |
USP7 degrader D16
USP7 PROTAC
|
USP7 degrader D16 is a potent and selective USP7 degrader with DC50 of 1.91 uM in TE-12 cells. |
| PC-28660 |
PRMT1 PROTAC 1
PRMT1 PROTAC
|
PRMT1 PROTAC 1 (Compound 4) is potent, first-in-class, selective PRMT1 PROTAC degrader with DC50 of 0.77 uM, Dmax of 84.83% in MCF-7 cells, exhibits highly potent PRMT1 degradation with DC50 of 0.65 7M and a Dmax of 93.03% in A2058 cells. |
| PC-28655 |
AURKA PROTAC CT3
AURKA PROTAC
|
AURKA PROTAC CT3 is a potent, selective a potent and subtype-selective AURKA degrader with DC50 of 25.62 nM, displays antiproliferative activity against Jurkat cells with IC50 of 0.81 uM, shows >40-fold AURKB and AURKC selectivity. |
| PC-28654 |
KRAS G12D PROTAC VI-1
KRAS G12D degrader
|
KRAS G12D PROTAC VI-1 is a potent, selective KRAS G12D PROTAC degrader, exhibits anti-proliferative activity with IC50 of 4.27 uM (PANC-1). |
| PC-28653 |
DNMT1 degrader 6k
DNMT1 degrader
|
DNMT1 degrader 6k is a highly potent and selective DNMT1 degrader with IC50 of 202.87 nM and Kd value of 122 nM, promotes significant direct interaction between DNMT1 and UHRF1 proteins via a molecular glue mechanism, exhibits potent inhibitory effects on AML cells both in vitro and in vivo. |
| PC-28651 |
SAMHD1 degrader NP12
SAMHD1 PROTAC
|
SAMHD1 degrader NP12 is a potent, specific SAMHD1 degrader with DC50 of 1.2 uM and Dmax=89% in THP-1 cells (48h). |
| PC-28650 |
THNAN69
LIMK2 PROTAC
|
THNAN69 is a potent, isoform-specific LIMK2 PROTAC degrader with IC50 of 80 nM in NanoBRET binding assays, DC50 of 1 nM in live-cell EGFP-LIMK2 assays. |
| PC-28649 |
CB039
RBM39 degrader
|
CB039 is a potent RBM39 molecular glue degrader with cell growth inhibition IC50 of 36.7 nM against HCT-116 cells. |
| PC-28648 |
YSA64
RBM39 degrader
|
YSA64 is a potent, biphenyl-containing RBM39 molecular glue degrader, shows potent antiproliferative activity with IC50 of 166 nM for HCT-116 cells. |
| PC-28647 |
GSI526
IRAK4 PROTAC
|
GSI526 is a potent efficient IRAK4 degrader with DC50 of 40.17 nM in THP-1 cells (Dmax=97%), acts via the ubiquitin-proteasome system, effectively suppressing the IRAK4-mediated NF-κB and MAPK signaling pathways. |
