THNAN69 | LIMK2 PROTAC | Probechem Biochemicals

Chemical Structure : THNAN69

加入收藏

THNAN69 (THNAN-69)

货号: PC-28650Not For Human Use, Lab Use Only.

THNAN69 is a potent, isoform-specific LIMK2 PROTAC degrader with IC50 of 80 nM in NanoBRET binding assays, DC50 of 1 nM in live-cell EGFP-LIMK2 assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

THNAN69 is a potent, isoform-specific LIMK2 PROTAC degrader with IC50 of 80 nM in NanoBRET binding assays, DC50 of 1 nM in live-cell EGFP-LIMK2 assays.
THNAN69 induces isoform-specific ubiquitin-mediated degradation of LIMK2 by recruiting the CRBN E3 ligase, forming a stable ternary complex with LIMK2 and CRBN, which is dependent on the activity of cullin-RING ligase.
THNAN69 also stimulates compensatory activation of the Rho signaling pathway including PAK1/2 and ROCK1/2.
THNAN69 is highly selective in proteome-wide screens.

物理化学性质&存储条件

分子量	744.60
分子式	C32H29Cl2F2N9O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)-5-(4-((3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methylphenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentanamide

参考文献

1. Azeez KRA, et al. ACS Chem Biol. 2026 May 15;21(5):1158-1176.

THNAN69 (THNAN-69)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

THNAN69 (THNAN-69)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.