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首页-抗体药物偶连体和PROTACs-PROTAC-AURKA PROTAC CT3
AURKA PROTAC CT3

Chemical Structure : AURKA PROTAC CT3

CAS No.: 3135155-78-8

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AURKA PROTAC CT3

货号: PC-28655Not For Human Use, Lab Use Only.

AURKA PROTAC CT3 is a potent, selective a potent and subtype-selective AURKA degrader with DC50 of 25.62 nM, displays antiproliferative activity against Jurkat cells with IC50 of 0.81 uM, shows >40-fold AURKB and AURKC selectivity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AURKA PROTAC CT3 is a potent, selective a potent and subtype-selective AURKA degrader with DC50 of 25.62 nM, displays antiproliferative activity against Jurkat cells with IC50 of 0.81 uM, shows >40-fold AURKB and AURKC selectivity.

物理化学性质&存储条件

分子量 918.46
分子式 C48H48ClN7O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-chloro-3-(pyridin-2-yloxy)phenyl)-N-((4-(10-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)dec-9-ynoyl)piperazin-1-yl)sulfonyl)-7-methyl-1H-indole-6-carboxamide

参考文献

1. Ye Y, et al. J Med Chem. 2026 Aug 13;69(15):18414-18430.

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