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首页-抗体药物偶连体和PROTACs-PROTAC-GSI526
GSI526

Chemical Structure : GSI526

CAS No.:

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GSI526 (GSI-526)

货号: PC-28647Not For Human Use, Lab Use Only.

GSI526 is a potent efficient IRAK4 degrader with DC50 of 40.17 nM in THP-1 cells (Dmax=97%), acts via the ubiquitin-proteasome system, effectively suppressing the IRAK4-mediated NF-κB and MAPK signaling pathways.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSI526 is a potent efficient IRAK4 degrader with DC50 of 40.17 nM in THP-1 cells (Dmax=97%), acts via the ubiquitin-proteasome system, effectively suppressing the IRAK4-mediated NF-κB and MAPK signaling pathways.

物理化学性质&存储条件

分子量 973.21
分子式 C52H64N10O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(2-(6-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoyl)-2,7-diazaspiro[3.5]nonan-7-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide

参考文献

1. Bingjie Yin, et al. Bioorg Med Chem Lett. 2026 Sep:138:130680.

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