PRMT1 PROTAC 1

Chemical Structure : PRMT1 PROTAC 1

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货号: PC-28660Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PRMT1 PROTAC 1 (Compound 4) is potent, first-in-class, selective PRMT1 PROTAC degrader with DC50 of 0.77 uM, Dmax of 84.83% in MCF-7 cells, exhibits highly potent PRMT1 degradation with DC50 of 0.65 7M and a Dmax of 93.03% in A2058 cells.
PRMT1 PROTAC 1 triggers dose- and time-dependent degradation of the PRMT1 protein.
PRMT1 PROTAC 1 reduces PRMT1 protein levels in MCF-7 cells through a proteasome-dependent and CRBN E3 ligase mechanism.
PRMT1 PROTAC 1 decreases global aDMA levels and asymmetric dimethylation of arginine 3 on histone H4 (H4R3me2a) levels in MCF-7 cells.
PRMT1 PROTAC 1 effectively inhibits colony formation at low concentrations, with activity against A2058 cells observed at 1.25 μM.

物理化学性质&存储条件

分子量	752.96
分子式	C43H56N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(12-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)dodecyl)-4-(2-((methyl(2-(methylamino)ethyl)amino)methyl)phenoxy)benzamide

参考文献

1. Guo S, et al. J Med Chem. 2026 Mar 26;69(6):6775-6789.

PRMT1 PROTAC 1

生物&药学活性

物理化学性质&存储条件

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PRMT1 PROTAC 1

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