USP7 degrader D16

Chemical Structure : USP7 degrader D16

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货号: PC-28661Not For Human Use, Lab Use Only.

USP7 degrader D16 is a potent and selective USP7 degrader with DC50 of 1.91 uM in TE-12 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP7 degrader D16 is a potent and selective USP7 degrader with DC50 of 1.91 uM in TE-12 cells.
D16 degrades USP7 in KYSE-150 and MGC-803 cells with DC50 = 2.53 μM and 4.01 μM, respectively.
D16 degrades USP7 through the formation of USP7-D16-CRBN ternary complex and subsequent proteasome degradation.
D16 prevents migration of UGI cancer cells.

物理化学性质&存储条件

分子量	823.37
分子式	C42H43ClN8O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5-(3-((7-(5-chloro-3-methyl-2-(piperidin-3-ylamino) phenyl) thieno [3,2-b] pyridin-2-yl) methyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) pentyl) amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Ma XB, et al. Eur J Med Chem. 2026 Feb 15;304:118488.