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首页-抗体药物偶连体和PROTACs-PROTAC-DNMT1 degrader 6k
DNMT1 degrader 6k

Chemical Structure : DNMT1 degrader 6k

CAS No.: 2962943-72-0

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DNMT1 degrader 6k (DNMT1 Degrader-1)

货号: PC-28653Not For Human Use, Lab Use Only.

DNMT1 degrader 6k is a highly potent and selective DNMT1 degrader with IC50 of 202.87 nM and Kd value of 122 nM, promotes significant direct interaction between DNMT1 and UHRF1 proteins via a molecular glue mechanism, exhibits potent inhibitory effects on AML cells both in vitro and in vivo.

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25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DNMT1 degrader 6k is a highly potent and selective DNMT1 degrader with IC50 of 202.87 nM and Kd value of 122 nM, promotes significant direct interaction between DNMT1 and UHRF1 proteins via a molecular glue mechanism, exhibits potent inhibitory effects on AML cells both in vitro and in vivo.

物理化学性质&存储条件

分子量 408.55
分子式 C24H32N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(cyclopent-1-en-1-yl)-6,7-dimethoxy-4-(4-(pyrrolidin-1-yl)piperidin-1-yl)quinazoline

参考文献

1. Lan Ma, et al. J Med Chem. 2026 Apr 9;69(7):7756-7781.

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