欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-抗体药物偶连体和PROTACs-PROTAC

Request The Product List ofPROTAC PROTAC

Cat. No. Product Name Information
PC-23542

dCK1α-1

CK1α degrader

dCK1α-1 (LC-04-087) is a potent and selective CK1α-targeting molecular glue degrader with DC50 of 12 nM, Dmax of 90% in MOLM13 cells (72 h).
PC-23448

ATC-324

AR AUTOTAC degrader

ATC-324 is a potent, selective androgen receptor (AR) AUTOphagy-TArgeting Chimera (AUTOTAC) degrader with DC50 of 2.05 uM in LNCaP cells, induces the formation of the AR/p62 complex, leading to autophagy-lysosomal degradation of AR.
PC-23445

TRIB2 PROTAC 5k

TRIB2 PROTAC

TRIB2 PROTAC 5k (Compound 5k) is a potent, selective pseudokinase TRIB2 PROTAC degrader with DC50 of 16.8 nM and Dmax of 92% in PC3 cells.
PC-23444

SD-436

STAT3 PROTAC

SD-436 is a highly potent and selective STAT3 PROTAC degrader with DC50 of 10 nM and Dmax >95% in SU-DHL-1 lymphoma cell line.
PC-23413

WIZ degrader 10

WIZ degrader

WIZ degrader 10 is a potent, and selective molecular glue degrader of the transcription factor WIZ with DC50 of 3 nM and Dmax of 86%.
PC-23408

MDEG-541

MYC PROTAC

MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.
PC-23403

MS105

PTK6 PROTAC

MS105 is a potent, selective protein tyrosine kinase 6 (PTK6) ROTAC degrader, specifically and potently degrades PTK6 in a proteasome and VHL-dependent manner with DC50 of 21 nM and Dmax of 84% in MDA-MB-231/LM2-4 cells.
PC-23400

WEE1-CK1α molecular glue degrader 10

WEE1/CK1α degrader

WEE1-CK1α molecular glue degrader 10 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.6 nM and 1.5 nM in MOLT-4 cells respectively.
PC-23399

WEE1-CK1α molecular glue degrader 1

WEE1/CK1α degrader

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
PC-23385

MD-265

MDM2 PROTAC

MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53.
PC-23329

BRD9 PROTAC C6

BRD9 PROTAC

BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7.
PC-23323

BET PROTAC SIM1

BRD2 PROTAC

BET PROTAC SIM1 is a highly potent, von Hippel-Lindau (VHL)-based BET trivalent PROTAC degrader with preference for BRD2 with DC50 of 1.1 nM, 3.3 nM and 0.7 nM for RD2, BRD3, BRD4 in HEK293 cells, potently inhibits cell viability of MV4;11 AML cell line with IC50 of 1.1 nM (48 h).

Request The Product List

  • *分类名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *国籍:
  • 留言信息:

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com