INY-06-061 | ERK5 PROTAC | Probechem Biochemicals

Chemical Structure : INY-06-061

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INY-06-061 (ERK5 PROTAC degrader)

货号: PC-49380Not For Human Use, Lab Use Only.

INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment).

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生物&药学活性

INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment).
INY-06-061 displays a similar selectivity profile to both the parental inhibitor INY-06-086 and the original ERK5 inhibitor BAY-885.
INY-06-061-induced ERK5 degradation is dependent on the ubiquitin-proteasome system.
INY-06-061 treatment does not compromise viability in multiple cancer cell lines, does not affect pro-inflammatory cytokine secretion in endothelial cells.

物理化学性质&存储条件

分子量	1041.249
分子式	C54H67F3N10O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(6-(4-(4-(1-(2-amino-4-(trifluoromethoxy)benzoyl)piperidin-4-yl)quinazolin-7-yl)piperazin-1-yl)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Inchul You, et al. Cell Chem Biol. 2022 Oct 6;S2451-9456(22)00352-X.

INY-06-061 (ERK5 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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INY-06-061 (ERK5 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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