| Cat. No. |
Product Name |
Information |
| PC-21068 |
JH-XII-03-02
LRRK2 PROTAC
|
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S. |
| PC-21045 |
KYH1872
PROTAC
|
KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker. |
| PC-21044 |
DB0614
PROTAC
|
DB0614 is a CRBN-based PROTAC, induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells. |
| PC-20816 |
PTD10
BTK PROTAC
|
PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853. |
| PC-20680 |
MRT-2359
GSPT1 PROTAC
|
MRT-2359 (MRT2359) is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader with DC50 of 5 nM in CAL51 cell line (Dmax=100%). |
| PC-20653 |
DeFer-2
Ferritin PROTAC
|
DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis. |
| PC-73289 |
BSJ-04-132
CDK4 degrader
|
BSJ-04-132 is a selective CDK4 degrader (PROTAC), does not induce IKZF1/3 degradation. |
| PC-73288 |
BSJ-03-204
CDK4/6 degrader
|
BSJ-03-204 is a dual and selective degrader (PROTAC) of CDK 4 and 6, does not induce IKZF1/3 degradation. |
| PC-73165 |
ERD-308
Estrogen receptor PROTAC
|
ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively. |
