| Cat. No. |
Product Name |
Information |
| PC-22647 |
SJ11646
LCK PROTAC
|
SJ11646 is a potent, dasatinib-based, cereblon-mediated LCK PROTAC degrader with DC50 of 0.00838 pM in in KOPT-K1 T-ALL cells, cytotoxic IC50 of 0.083pM. |
| PC-22646 |
SJ45566
LCK PROTAC
|
SJ45566 is a potent, selective and orally active dasatinib-based LCK PROTAC degrader with DC50 of 1.21 nM (Dmax 98%) in KOPT-K1 cells. |
| PC-22590 |
UNC10088
NSD2 degrader
|
UNC10088 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22589 |
UNC8732 TFA
NSD2 degrader
|
UNC8732 TFA is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22588 |
UNC8732
NSD2 degrader
|
UNC8732 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22587 |
PLX-3618
BRD4 degrader
|
PLX-3618 is a potent, selective monovalent direct degrader of BRD4 (DC50=12.2 nM, HEK293T cells) that acts via the Recruitment of DCAF11, elicits UPS-mediated selective degradation of BRD4, resulting in potent antitumor activity in vitro and in vivo. |
| PC-22585 |
dWIZ-1
WIZ degrader
|
dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22578 |
XZ9002
HDAC3 degrader
|
XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells. |
| PC-22577 |
YX862
HDAC8 degrader
|
YX862 is a highly potent and selective hydrazide-based HDAC8-PROTAC degrader with DC50 values of 2.6 nM in MDA-MB-231 and 1.8 nM in MCF-7 cells. |
| PC-22559 |
GNF-2-deg
Flaviviruse E protein PROTAC
|
GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism. |
| PC-22558 |
2-12-2-deg
Flaviviruse E protein PROTAC
|
2-12-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.21 uM, Dmax of 95%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism. |
| PC-22554 |
ARCC-4
AR degrader
|
ARCC-4 is a potent, selective enzalutamide-based von Hippel-Lindau (VHL)-recruiting androgen receptor (AR) degrader with DC50 of 5 nM in VCaP cells. |
