M4K3233

Chemical Structure : M4K3233

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货号: PC-26691Not For Human Use, Lab Use Only.

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

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生物&药学活性

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

物理化学性质&存储条件

分子量	772.90
分子式	C44H48N6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-Dioxo-3-piperidyl)-5-[4-[[4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenyl]piperazin-1-yl]methyl]-1-piperidyl]isoindoline-1,3-dione

参考文献

1. Daniel T Webb, et al. J Med Chem. 2026 May 3. doi: 10.1021/acs.jmedchem.6c00714.

M4K3233

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物理化学性质&存储条件

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M4K3233

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