MGD-28

Chemical Structure : MGD-28

CAS No.: 2991818-13-2

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货号: PC-26524Not For Human Use, Lab Use Only.

MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM).

物理化学性质&存储条件

分子量	595.68
分子式	C33H34FN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-3-methyl-1-oxo-1,2,3,4-tetrahydrophthalazin-5-yl)amino)methyl)benzyl)piperazin-1-yl)-2-fluorobenzonitrile

参考文献

1. Pengyun Li, et al. J Hematol Oncol. 2024 Sep 2;17(1):77.

MGD-28

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物理化学性质&存储条件

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MGD-28

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物理化学性质&存储条件

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