MS108 | ENL PROTAC | Probechem Biochemicals

Chemical Structure : MS108

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MS108 (MS-108)

货号: PC-26640Not For Human Use, Lab Use Only.

MS108 is a potent, selective eleven-nineteen leukemia protein (ENL) PROTAC degrader with DC50 of 0.6 nM and Dmax > 97% in MV4;11 cells.

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生物&药学活性

MS108 is a potent, selective eleven-nineteen leukemia protein (ENL) PROTAC degrader with DC50 of 0.6 nM and Dmax > 97% in MV4;11 cells.
MS108 induces robust and highly selective degradation of ENL in a concentration-, time-, VHL-, and ubiquitin-proteasome system (UPS)-dependent manner.
MS108 potently suppresses proliferation and clonogenic growth across multiple cancer cell lines, with 6- to 20-fold lower GI50 values compared to MS41.
MS108 displays sufficient plasma exposure in a mouse pharmacokinetic (PK) study via intraperitoneal (IP) administration.

物理化学性质&存储条件

分子量	1041.28
分子式	C56H68N10O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(Dimethylcarbamoyl)-3-hydroxyphenyl)-N-((R)-6-((8-(1-((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-1H-1,2,3-triazol-4-yl)octyl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)isoxazole-3-carboxamide

参考文献

1. Luo K, et al. J Med Chem. 2026 Apr 23. doi: 10.1021/acs.jmedchem.6c00386.

MS108 (MS-108)

生物&药学活性

物理化学性质&存储条件

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MS108 (MS-108)

生物&药学活性

物理化学性质&存储条件

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