UNC8209 | TBK1 PROTAC | Probechem Biochemicals

Chemical Structure : UNC8209

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UNC8209 (UNC-8209)

货号: PC-26520Not For Human Use, Lab Use Only.

UNC8209 is a a selective cereblon-recruiting PROTAC degrader of TANK-binding kinase 1 (TBK1) with DC50 of 80 nM and 23 nM in A498 and 769-P cells respectively.

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100 mg		Get quote

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生物&药学活性

UNC8209 is a a selective cereblon-recruiting PROTAC degrader of TANK-binding kinase 1 (TBK1) with DC50 of 80 nM and 23 nM in A498 and 769-P cells respectively.
UNC8209 mediates TBK1 degradation through the CRBN-dependent ubiquitin-proteasome pathway.
UNC8209 displays high selectivity for TBK1 degradation over its homolog IKKε.
UNC8209 effectively suppressed proliferation in the majority of VHL-deficient RCC lines.
UNC8209 exerts growth-inhibitory activity in ccRCC tumorigenesis.

物理化学性质&存储条件

分子量	968.90
分子式	C45H58BrN7O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((5-bromo-2-((4-((18-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-3,6,9,12,15-pentaoxaoctadecyl)oxy)phenyl)amino)pyrimidin-4-yl)amino)propyl)-N-methylcyclobutanecarboxamide

参考文献

1. Liao C, et al. Cell Chem Biol. 2026 Apr 7:S2451-9456(26)00105-4.

UNC8209 (UNC-8209)

生物&药学活性

物理化学性质&存储条件

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UNC8209 (UNC-8209)

生物&药学活性

物理化学性质&存储条件

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