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首页-抗体药物偶连体和PROTACs-PROTAC-M4K3250
M4K3250

Chemical Structure : M4K3250

CAS No.:

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M4K3250

货号: PC-26692Not For Human Use, Lab Use Only.

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.9 in HEK-293 cells and Dmax=78%, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.9 in HEK-293 cells and Dmax=78%, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

物理化学性质&存储条件

分子量 760.87
分子式 C43H45FN6O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,6-Dioxopiperidin-3-yl)-5-(4-((4-(4-(5-(4-fluoro-3,5-dimethoxyphenyl)-4-methylpyridin-3-yl)phenyl)piperazin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione

参考文献

1. Daniel T Webb, et al. J Med Chem. 2026 May 3. doi: 10.1021/acs.jmedchem.6c00714.

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