| Cat. No. |
Product Name |
Information |
| PC-73296 |
QC-01-175
Tau PROTAC
|
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC). |
| PC-73287 |
HDAC8 PROTAC 1
HDAC8 degrader
|
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells. |
| PC-73152 |
ACBI1
SMARCA2/SMARCA4 PROTAC
|
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively. |
| PC-73109 |
SD-36
STAT3 PROTAC
|
SD-36 (STAT3 degrader SD-36) is a potent, selective STAT3 degrader (PROTAC), potently induces the degradation of STAT3 protein in vitro and in vivo. |
| PC-73098 |
YKL-06-101
CDK8 PROTAC
|
YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM). |
| PC-72930 |
YTK-105 linker conjugate 1
AUTOTAC conjugate
|
YTK-105 linker conjuate 1 is a PEG linker added to p62-ZZ ligand YTK-105 for AUTOTAC design. |
| PC-72929 |
YOK-2204 linker conjugate 1
AUTOTAC conjugate
|
YOK-2204 linker conjuate 1 is a PEG linker added to p62-ZZ ligand YOK-2204 for AUTOTAC design. |
| PC-72928 |
YOK-1304 AUTOTAC intermidate 1
AUTOTAC conjugate
|
YOK-1304 AUTOTAC intermidate 1 is an intermidate for AUTOTAC design. |
| PC-72927 |
p62-ZZ ligand YTK-105
p62-ZZ ligand
|
YTK-105 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design. |
| PC-72911 |
GNE-987
BET degrader
|
GNE-987 (GNE987) is a highly potent chimeric BET degrader, exhibits BRD4 degradation activity in EOL-1 AML cell line with DC50 of 30 pM. |
| PC-72840 |
MS9715
NSD3 PROTAC
|
MS9715 (MS 9715) is a NSD3-targeting PROTAC designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand. |
| PC-72837 |
NJH-2-057
CFTR DUBTAC
|
NJH-2-057 is a novel CFTR DUBTAC via linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor with C5 alkyl linkers. |
