| Cat. No. |
Product Name |
Information |
| PC-38566 |
STING PROTAC SP23
STING PROTAC
|
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM. |
| PC-38462 |
dBRD9 dihydrochloride
BRD9 PROTAC
|
dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
| PC-73343 |
YX-2-115
CDK6 inhibitor
|
YX-2-115 is a palbociclib derivative compound with piperazine-linker tail for PROTAC YX-2-107 synthesis, inhibits CDK6 with IC50 of 4.5 nM. |
| PC-73342 |
YX-2-107
CDK6 PROTAC
|
YX-2-107 is a CRBN-recruiting and specific CDK6-degrading PROTAC with IC50 of 0.69 and 4.4 nM for CDK4 and CDK6 in vitro, selectively degardes CDK6 in Ph+ BV173 ALL cells with a degradation constant of 4 nM. |
| PC-73321 |
CFT7455
IKZF1/3 degrader
|
Cemsidomide (CFT7455) is a highly potent and selective degarder of IKZF1/3 with cereblon binding IC50 of 0.4 nM and picomolar DC50. |
| PC-73316 |
CFT8634
BRD9 BiDAC degrader
|
CFT-8634 (CFT8634) is a potent, selective, orally bioavailable BRD9 BiDAC degrader with DC50 of 3 nM, high selectivity over BRD4 abd BRD7. |
| PC-73310 |
CFT-14441
BRD9 BiDAC degrader
|
CFT-14441 is a potent and selective BRD9 BiDAC degrader with DC50 of 39 nM (2h), high selectivity over BRD4 abd BRD7. |
| PC-73296 |
QC-01-175
Tau PROTAC
|
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC). |
| PC-73287 |
HDAC8 PROTAC 1
HDAC8 degrader
|
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells. |
| PC-73152 |
ACBI1
SMARCA2/SMARCA4 PROTAC
|
ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively. |
| PC-73109 |
SD-36
STAT3 PROTAC
|
SD-36 (STAT3 degrader SD-36) is a potent, selective STAT3 degrader (PROTAC), potently induces the degradation of STAT3 protein in vitro and in vivo. |
| PC-73098 |
YKL-06-101
CDK8 PROTAC
|
YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM). |
