IBG4 | BRD4 degrader | Probechem Biochemicals

Chemical Structure : IBG4

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IBG4 (BRD4 degrader)

货号: PC-21847Not For Human Use, Lab Use Only.

IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2.

物理化学性质&存储条件

分子量	647.73
分子式	C34H30FN9O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4'-(6-(2-(dimethylamino)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-4-fluoro-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

参考文献

1. Oliver Hsia, et al. Nature. 2024 Feb 21. doi: 10.1038/s41586-024-07089-6.