DAS-CHO-5-oCRBN | c-Src PROTAC | Probechem Biochemicals

Chemical Structure : DAS-CHO-5-oCRBN

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DAS-CHO-5-oCRBN (c-Src PROTAC degrader)

货号: PC-21653Not For Human Use, Lab Use Only.

DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells.

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2 mg	￥3980	In stock
5 mg	￥5980	In stock
10 mg	￥8580	In stock
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100 mg		Get quote

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生物&药学活性

DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells.
DAS-CHO-5-oCRBN does not significantly inhibit the c-Src signaling in cells.
DAS-CHO-5-oCRBN exhibits antiproliferative activity in c-Src-dependent cell lines (MDA-MB-231, GI50=62 nM) with similar pharmacology to siRNA knockdown of c-Src.

物理化学性质&存储条件

分子量	883.99
分子式	C45H45N11O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((6-(4-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazin-1-yl)-2-oxoethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-N-(2-methyl-4-phenoxyphenyl)thiazole-5-carboxamide

参考文献

1. Mao W, et al. ACS Chem Biol. 2023 Dec 19. doi: 10.1021/acschembio.3c00548.

DAS-CHO-5-oCRBN (c-Src PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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DAS-CHO-5-oCRBN (c-Src PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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