| Cat. No. |
Product Name |
Information |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-23651 |
PARP1 PROTAC 180055
PARP1 PROTAC
|
PARP1 PROTAC 180055 is a potent, PARP1-specific degradation PROTAC compound with DC50 of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. |
| PC-23566 |
YB-3-17
GSPT1 degrader, mTOR inhibitor
|
YB-3-17 is a potent dual-target, dual-mechanism molecule, robustly inhibits mTOR (IC50=0.22 nM) and selectively degrades GSPT1 (DC50=5 nM, U87 cells). |
| PC-23565 |
LZK PROTAC-21A
LZK PROTAC
|
LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM. |
| PC-23554 |
YZ-836P
PRMT5 PROTAC
|
YZ-836P is a CRBN-recruiting PRMT5 PROTAC degrader, exerts cytotoxic effects in TNBC, promotes the ubiquitination and degradation of PRMT5 in a CRBN-dependent manner, downregulates key downstream target protein KLF5 in TNBC. |
| PC-23543 |
dCK1α-2
CK1α degrader
|
dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells. |
| PC-23542 |
dCK1α-1
CK1α degrader
|
dCK1α-1 (LC-04-087) is a potent and selective CK1α-targeting molecular glue degrader with DC50 of 12 nM, Dmax of 90% in MOLM13 cells (72 h). |
| PC-23448 |
ATC-324
AR AUTOTAC degrader
|
ATC-324 is a potent, selective androgen receptor (AR) AUTOphagy-TArgeting Chimera (AUTOTAC) degrader with DC50 of 2.05 uM in LNCaP cells, induces the formation of the AR/p62 complex, leading to autophagy-lysosomal degradation of AR. |
| PC-23445 |
TRIB2 PROTAC 5k
TRIB2 PROTAC
|
TRIB2 PROTAC 5k (Compound 5k) is a potent, selective pseudokinase TRIB2 PROTAC degrader with DC50 of 16.8 nM and Dmax of 92% in PC3 cells. |
