BGB-16673 (BGB16673)

Chemical Structure : BGB-16673

CAS No.: 2736508-94-2

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货号: PC-21567Not For Human Use, Lab Use Only.

BGB-16673 is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination.

规格	价格	库存
2 mg	￥2980	In stock
5 mg	￥5880	In stock
10 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BGB-16673 is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination.
BGB-16673 exhibits high potency on clinically relevant BTK mutants resistant to covalent and non-covalent BTK inhibitors in cancer cells in vitro.
BGB-16673 drives complete tumor regression of lymphoma xenograft models expressing wildtype or BTK mutations resistant to covalent and non-covalent inhibitors.
BGB-16673 presents longer duration of response than BTK inhibitors in BTK wildtype and C481S mutant-expressing lymphoma xenograft models.

物理化学性质&存储条件

分子量	850.04
分子式	C48H55N11O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(tert-butyl)-N-((1R)-1-(4-(6-(6-(4-((1-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methylphenyl)ethyl)-1,2,4-oxadiazole-5-carboxamide

参考文献

1. John F. Seymour, et al. Blood (2023) 142 (Supplement 1): 4401.