SelDeg51 | FKBP51 PROTAC | Probechem Biochemicals

Chemical Structure : SelDeg51

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SelDeg51 (Selective Degrader of FKBP51)

货号: PC-21336Not For Human Use, Lab Use Only.

SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC degrader with Kd of 18 nM, Emax=90%.

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生物&药学活性

SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC degrader with Kd of 18 nM, Emax=90%.
SelDeg51 increases the Dexamethasone-induced expression of the endogenous GR target genes GILZand FKBP5, reflecting the removal of FKBP51-mediated repression of GR signalling.

物理化学性质&存储条件

分子量	1343.62
分子式	C72H91FN8O14S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-3-(3,4-dimethoxyphenyl)-1-(4-((1-(3-(2-(((2S,4R)-1-(2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)propyl (2S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate

参考文献

1. Thomas M Geiger, et al. Angew Chem Int Ed Engl. 2023 Nov 9:e202309706.

SelDeg51 (Selective Degrader of FKBP51)

生物&药学活性

物理化学性质&存储条件

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SelDeg51 (Selective Degrader of FKBP51)

生物&药学活性

物理化学性质&存储条件

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