| Cat. No. |
Product Name |
Information |
| PC-22155 |
MPD2
SARS-CoV-2 Mpro PROTAC
|
MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism. |
| PC-22120 |
ARV-393
BCL6 PROTAC
|
ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
| PC-22117 |
BMS-986365
AR degrader
|
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR. |
| PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
| PC-21992 |
LC-1-40
NUDT1 PROTAC
|
LC-1-40 is a potent, specific NUDT1 (MTH1) degrader/PROTAC with DC50 of 0.97 nM in SHEP MYCN-ER cells, Dmax value of 96% at 50 nM. |
| PC-21928 |
Dual BCL-xL, BCL-2 degrader 753b
BCL-xL/BCL-2 PROTAC
|
Dual BCL-xL/BCL-2 degrader 753b (Compound 753b) is a highly potent dual BCL-xL and BCL-2 PROTAC degrader with DC50 of 6 nM and 48 nM for degrading BCL-xL and BCL-2 in 293T cells respectively. |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells. |
| PC-21642 |
DBr-1
DCAF1-BRD9 PROTAC
|
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder. |
| PC-21567 |
BGB-16673
BTK PROTAC
|
BGB-16673 is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination. |
