| Cat. No. |
Product Name |
Information |
| PC-28712 |
ZX079
BRD4/CBP PROTAC
|
ZX079 is a potent, selective dual BRD4/CBP PROTAC degrader with DC50 of 0.035 nM and <0.02 nM in MV4-11 cells. |
| PC-28662 |
DIX-01
IKZF1/3 and GSPT1 degrader
|
DIX-01 is a potent dual IKZF1/3 and GSPT1 molecular glue degrader with DC50 values of 19.80 nM for IKZF1, 45.31 nM for IKZF3, and 120.1 nM for GSPT1 in MV4-11 cells. |
| PC-28627 |
GT19630
MYC/GSPT1 degrader
|
GT19630 (GT-19630) is a potent, dual MYC/GSPT1 protein degrader with IC50 of 1.5 nM against human c-Myc, inhibits cell proliferation, blocks cell cycle progression, induces apoptosis, and decreases cell migration in breast cancer cell lines. |
| PC-28354 |
MJP6412
p300/CBP PROTAC
|
MJP6412 is a potent, selective p300/CBP PROTAC degrader with DC50 of 1.6-3.4 nM for p300 and 1.2-3.7 nM for CBP in 22Rv1 cells, inhibits cell growth of 22Rv1 cells with IC50 of 37.6 nM. |
| PC-28072 |
NVP-KFA115
IKZF2/4 degrader
|
NVP-KFA115 (KFA115) is a potent, selective molecular glue degrader of IKZF2 (Helios) and IKZF4 (Eos). |
| PC-27988 |
RP04340
KRAS PROTAC
|
RP04340 is a potent and orally bioavailable pan-KRAS PROTAC degrader, potently degrades multiple KRAS mutants, without affecting HRAS, NRAS, or known CRBN neosubstrates. |
| PC-27888 |
ASM130
NUDT5 PROTAC
|
ASM130 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 7 nM in HEK293 cells (20h incubation), Dmax=73%. |
| PC-27887 |
ASM127
NUDT5 PROTAC
|
ASM127 is a potent and efficient NUDT5 PROTAC degrader with DC50 of 12 nM in HEK293 cells (20h incubation), Dmax=71%. |
| PC-27785 |
Z5000181945
RNF39 degrader
|
Z5000181945 is a small molecule glue degrader of E3 ubiquitin ligase RNF39, enhances the RNF39-CRBN interaction, induces degradation of the RNF39 RING finger domain, which is rescued by the NEDD8-activating enzyme (NAE) inhibitor MLN4924. |
| PC-27784 |
FIZ1 degrader 1
FIZ1 degrader
|
FIZ1 degrader 1 is a small molecule degrader zinc-finger protein FIZ1 (Flt3-interacting zinc finger protein 1). |
| PC-27736 |
DK-5070
GPX4 degrader
|
DK-5070 is a potent, selective UHRF1-recruiting degrader of GPX4 with DC50 of 17.4 nM, Dmax of 84% in in HT1080 cells (24 h). |
| PC-27715 |
dTAGV-1
FKBP12F36V PROTAC
|
dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins. |
