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首页-抗体药物偶连体和PROTACs-PROTAC-GT19630
GT19630

Chemical Structure : GT19630

CAS No.: 2883535-99-5

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GT19630 (GT-19630)

货号: PC-28627Not For Human Use, Lab Use Only.

GT19630 (GT-19630) is a potent, dual MYC/GSPT1 protein degrader with IC50 of 1.5 nM against human c-Myc, inhibits cell proliferation, blocks cell cycle progression, induces apoptosis, and decreases cell migration in breast cancer cell lines.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GT19630 (GT-19630) is a potent, dual MYC/GSPT1 protein degrader with IC50 of 1.5 nM against human c-Myc, inhibits cell proliferation, blocks cell cycle progression, induces apoptosis, and decreases cell migration in breast cancer cell lines.
GT19630 mediates the degradation of MYC, GSPT1, GSPT2, CK1 alpha, N-Myc, B7-H3 and XIAP, and disrupts the MYC-GSPT1 synergistic regulatory feedback loop.
GT19630 induces MYC degradation at as low as 0.75 nM in BT549 cells and at 1.5 nM in CAMA1 cells.
GT19630 inhibits cell growth was explored using a panel of 14 human breast cancer cell lines.
GT19630 (3 nM) decreased protein expression levels of B7-H3 in BT549, MDA-MB-468, and CAMA1 cells.
GT19630 is highly active in vivo in models of therapy-resistant hematologic malignancies, including Burkitt's lymphoma, acute myeloid leukemia (AML) and multiple myeloma.

物理化学性质&存储条件

分子量 614.66
分子式 C35H30N6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((2-(9H-pyrido[2,3-b]indol-9-yl)acetamido)methyl)benzyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide

参考文献

1. Nishida Y, et al. Blood. 2026 Aug 17:blood.2025030170.

2. Tang M, et al. Invest New Drugs. 2025 Feb;43(1):167-179.

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