| Cat. No. |
Product Name |
Information |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
| PC-25871 |
LAG-3 PROTAC-1
LAG-3 PROTAC
|
LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h). |
| PC-25828 |
KG-FP-003
TEAD PROTAC
|
KG-FP-003 is a potent, selective, and durable TEAD PROTAC degrader with biochemicals binding IC50 of 591 nM for CRBN, degrades all TEAD isoforms in NCI-H1299 cells (TEAD1, DC50= 6 nM, TEAD2 DC50= 68 nM, TEAD3 DC50 =12, TEAD4 DC50= 7 nM). |
| PC-25827 |
BCL6-760
BCL6 degrader
|
BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively. |
| PC-25762 |
p53 Y220C DUBTAC A1
p53 Y220C DUBTAC
|
p53 Y220C DUBTAC A1 is a bifunctional small molecule p53 Y220C-specific deubiquitinase-targeting chimera (DUBTAC) recruiting both p53 Y220C and the deubiquitinase OTUB1, effectively reactivates and deubiquitinates mutant p53 Y220C in vitro and in vivo. |
| PC-25742 |
WZS0347
MITF PROTAC
|
WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells. |
| PC-25737 |
OUN20985
CRBN degrader
|
Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN. |
| PC-25736 |
MRT-31619
CRBN degrader
|
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation. |
| PC-25719 |
BCL6 PROTAC A19
BCL6 PROTAC
|
BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells. |
| PC-25704 |
LD5097
RIPK1 PROTAC
|
LD5097 is a potent, selective RIPK1 PROTAC degrader with DC50 of 0.7 nM in Jurkat cells, Dmax=96% (24h). |
| PC-25693 |
STAT6 PROTAC 1
STAT6 PROTAC
|
STAT6 PROTAC 1 is a potent, selective STAT6 PROTAC degrader with DC50 of <1 nM. |
| PC-25610 |
ZJK-807
KRAS G12D PROTAC
|
ZJK-807 is a selective, cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC) degrader of KRASG12D with DC50 of 79.5 nM in AsPC-1 cells (Dmax=92%), with minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D) KRAS proteins. |
