JH-XIII-05-01

Chemical Structure : JH-XIII-05-01

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货号: PC-28199Not For Human Use, Lab Use Only.

JH-XIII-05-01 is a potent, dual IRAK1/IRAK4 degrader with enzymetic IC50 of 43 nM and 16 nM, DC50 of 65 nM and 3.6 uM respectively.

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生物&药学活性

JH-XIII-05-01 is a potent, dual IRAK1/IRAK4 degrader with enzymetic IC50 of 43 nM and 16 nM, DC50 of 65 nM and 3.6 uM respectively.
JH-XIII-05-01 showes superior antiproliferative activity compared with its nondegrading parental inhibitor JH-XI-82-01.
JH-XIII-05-01 enhances apoptosis and synergizes with covalent and noncovalent BTK inhibitors, BTK degraders, and the BCL-2 inhibitor venetoclax in MYD88 mutant lymphomas.

物理化学性质&存储条件

分子量	917.98
分子式	C46H51N11O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperidin-4-yl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl)-6-(1H-pyrazol-5-yl)picolinamide

参考文献

1. Hatcher JM, et al. ACS Med Chem Lett. 2026 Aug 26;17(9):1977-1988.

JH-XIII-05-01

生物&药学活性

物理化学性质&存储条件

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JH-XIII-05-01

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物理化学性质&存储条件

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