SMARCA2 4 MGD Compound 1 | SMARCA2/4 degrader | Probechem Biochemicals

Chemical Structure : SMARCA2 4 MGD Compound 1

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SMARCA2 4 MGD Compound 1 (SMARCA2/4 MGD Compound 1)

货号: PC-27544Not For Human Use, Lab Use Only.

SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173.

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生物&药学活性

SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173.

物理化学性质&存储条件

分子量	495.63
分子式	C29H33N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-amino-5-(8-(2-(3-(piperidin-1-yl)prop-1-yn-1-yl)pyridin-4-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazin-3-yl)phenol

参考文献

1. Rouhimoghadam M, et al. Cell Chem Biol. 2026 Jul 2:S2451-9456(26)00198-4.

SMARCA2 4 MGD Compound 1 (SMARCA2/4 MGD Compound 1)

生物&药学活性

物理化学性质&存储条件

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SMARCA2 4 MGD Compound 1 (SMARCA2/4 MGD Compound 1)

生物&药学活性

物理化学性质&存储条件

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