NE26394

Chemical Structure : NE26394

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货号: PC-27389Not For Human Use, Lab Use Only.

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生物&药学活性

NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins.
NE26394 has much weaker downregulation of the close homologue CDK6 with DC50 of >10 uM, shows no activity for kinases CDK1, CDK2, CDK5, CDK7, CDK9, GSK3α and GSK3β.
NE26394 is a selective CRBN-based molecular glue recruiting CDK4-INK4 complexes.
NE26394 inhibits RB-E2F pathway activity in CDK4-dependent cancer cells, broadly suppresses E2F target protein expression across CDK4-dependent and RB-proficient prostate cancer cell lines.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Patrick R. A. Zanon, et al. Discovery of CDK4-selective molecular glue degraders by high-throughput proteomics. BioRxiv. Posted June 22, 2026.

NE26394

生物&药学活性

物理化学性质&存储条件

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NE26394

生物&药学活性

物理化学性质&存储条件

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