dWBP4-1

Chemical Structure : dWBP4-1

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货号: PC-27387Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

dWBP4-1 is a potent, highly selective, CRBN-dependent, phenotypically silent molecular glue degrader of spliceosome-associated scaffold protein WBP4 with DC50 of 3.4 nM in in MOLT-4 cells (Dmax=88%, 6h).
dWBP4-1 exhibits exceptional proteome-wide selectivity with negligible transcriptomic or alternative splicing perturbation.
WBP4-1 (100 nM) induced rapid and robust WBP4degradation as early as 30 min post-treatment in MOLT-4 cells via immunoblot analysis.
dWBP4-1 selectively degraded WBP4 without affecting other canonical IMiD targetsor spliceosomal components such as SNRPB2, WBP11, SF3B1-4, and SNRNP200.
dWBP4-1 efficiently mediates the proximity of CRBN and WBP4 with EC50 of 224 nM.
WW domain-binding protein 4 (WBP4), originally identifiedas formin-binding protein 21 (FBP21), is a 376-residue proteincharacterized by two tandem WW domains and a zinc-fingermotif, is a critical component of the RNA splicingmachinery.

物理化学性质&存储条件

分子量	496.57
分子式	C29H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(5-(4-(naphthalen-1-ylmethyl)piperazine-1-carbonyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Liu Y, et al. Angew Chem Int Ed Engl. 2026 Jul 28:e1973691.

dWBP4-1

生物&药学活性

物理化学性质&存储条件

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dWBP4-1

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