| Cat. No. |
Product Name |
Information |
| PC-72798 |
AU-15330
SWI/SNF ATPase PROTAC
|
AU-15330 (AU15330) is a highly specific and VHL-dependent PROTAC degrader of SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1), shows preferential cytotoxicity in enhancer-binding transcription factor-addicted cancers at low nanomolar concentrations. |
| PC-72782 |
GSK215
FAK PROTAC
|
GSK215 is a potent, selective, FAK-degrading Proteolysis Targeting Chimera (PROTAC) based on a binder for the VHL E3 ligase and the known FAK inhibitor VS-4718. |
| PC-72644 |
CFT-2718
BRD4 PROTAC
|
CFT-2718 (CFT2718) is a benzotriazoloazepine-based BRD4 degrader, rapidly and selectively degrade BRD4 in vitro in a CRBN-dependent manner (DC90=10 nM, 293T cells). |
| PC-72621 |
ARV-471
ER degrader
|
ARV-471 (Vepdegestrant) is an investigational orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) with DC50 of 1.8 nM. |
| PC-72572 |
SR-1114
ENL degarder
|
SR-1114 (SR1114) is a first-in-class ENL PROTAC degarder based on SR-0813 that binds to the E3 substrate adapter cereblon (CRBN), elicits rapid CRBN-dependent degradation of ENL with DC50 of 150 nM in MV4;11 cells. |
| PC-72497 |
INY-03-041
AKT PROTAC
|
INY-03-041 a pan-AKT degrader (PROTAC) consisting of AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). |
| PC-72479 |
IRAK3 PROTAC 23
IRAK3 PROTAC
|
IRAK3 PROTAC 23 a potent and selective degrader of IRAK3 with DC50 of 2 nM, with a maximum degradation measured of 98%. |
| PC-72325 |
MS910
MEK1/2 degrader
|
MS910 (MS-910) is the first CRBN-recruiting MEK1/2 degrader (PROTC) with HT29 DC50 of 118/55 nM for MEK1/2 degradation, respectively. |
| PC-72324 |
MS934
MEK1/2 degrader
|
MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively. |
| PC-72322 |
dBRD9-A
BRD9 PROTAC
|
dBRD9-A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations. |
| PC-72309 |
DGY-09-192
FGFR degrader
|
DGY-09-192 is a bivalent degrader (PROTAC) that couples the pan-FGFR inhibitor BGJ398 to a CRL2VHL E3 ligase recruiting ligand,preferentially induces FGFR1/2 degradation while largely sparing FGFR3/4. |
| PC-72308 |
HPK1 PROTAC SS47
HPK1 degrader
|
HPK1 PROTAC SS47 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
