| Cat. No. |
Product Name |
Information |
| PC-23961 |
DEG-35
IKZF2/CK1α degrader
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
| PC-23910 |
QZ2135
RET PROTAC
|
QZ2135 is a potent, selective RET PROTAC degrader, effectively degrades RET kinase (DC50=4.7 nM) and its resistant mutants, such as V804M (DC50=17.2 nM) and G810C/R. |
| PC-23898 |
FTO PROTAC QP73
FTO degrader
|
FTO PROTAC QP73 is a first-in-class PROTAC degrader for the RNA demethylase FTO, efficiently induces FTO protein degradation in a dose-, time-, cereblon (CRBN)-, and proteasome-dependent manner in AML cells (DC50=34.9 nM, NB4 cells). |
| PC-23836 |
Gridegalutamide
AR degrader
|
Gridegalutamide (BMS-986409) is an orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. |
| PC-23772 |
HLB-0532259
Aurora-A PROTAC
|
HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells. |
| PC-23702 |
CQ627
RIOK2 degrader
|
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126. |
| PC-23675 |
SMD-3040
SMARCA2 PROTAC
|
SMD-3040 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 12 nM and Dmax = 96% in Hela cells, >500-fold selectivity over SMARC4. |
| PC-23674 |
SMD-3236
SMARCA2 PROTAC
|
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4. |
| PC-23554 |
YZ-836P
PRMT5 PROTAC
|
YZ-836P is a CRBN-recruiting PRMT5 PROTAC degrader, exerts cytotoxic effects in TNBC, promotes the ubiquitination and degradation of PRMT5 in a CRBN-dependent manner, downregulates key downstream target protein KLF5 in TNBC. |
| PC-23448 |
ATC-324
AR AUTOTAC degrader
|
ATC-324 is a potent, selective androgen receptor (AR) AUTOphagy-TArgeting Chimera (AUTOTAC) degrader with DC50 of 2.05 uM in LNCaP cells, induces the formation of the AR/p62 complex, leading to autophagy-lysosomal degradation of AR. |
| PC-23444 |
SD-436
STAT3 PROTAC
|
SD-436 is a highly potent and selective STAT3 PROTAC degrader with DC50 of 10 nM and Dmax >95% in SU-DHL-1 lymphoma cell line. |
| PC-23408 |
MDEG-541
MYC PROTAC
|
MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1. |
