| Cat. No. |
Product Name |
Information |
| PC-49622 |
MS147
PRC1 degrader
|
MS147 (MS 147) is the first degrader of PRC1 core components, BMI1 and RING1B, comprises an EED small-molecule binder (EED226, Cat. PC-42321) linked to a ligand of the E3 ligase von Hippel-Lindau (VHL), degrades BMI1/RING1B in an EED-, VHL-, ubiquitination-, and time-dependent manner. |
| PC-49594 |
MS6105
LDHA/B PROTAC
|
MS6105 is the first lactate dehydrogenase (LDH) proteolysis targeting chimera (PROTAC) degrader, degrads both LDHA and LDHB significantly with DC50 of 38 and 74 nM in PANC-1 cells, respectively. |
| PC-49535 |
BJG-05-039
PAK1 PROTAC
|
BJG-05-039 is a potent, PAK1-selective PROTAC degrader consisting of NVS-PAK1-1 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon, shows potent in vitro inhibition of PAK1 (IC50 = 233 nM). |
| PC-49507 |
MS67
WDR5 PROTAC
|
MS67 is a highly effective, selective WDR5 degrader (PROTAC), contains the E3 ligase ligand VHL-1 and WDR5 binding moiety, shows binding affinities to VCB (Kd=140 nM) and WDR5 (Kd=63 nM), potently and selectively degrades WDR5 in MLL-r AML and PDAC cells. |
| PC-49454 |
A947
SMARCA2 PROTAC
|
A-947 (A947) is a potent and selective PROTAC targeting SMARCA2, potently degrades SMARCA2 in SW1573 cells with DC50 value of 39 pM, maximal degradation of 96% at 10 nM. |
| PC-49439 |
CRBN(FLT3)-8
FLT3-ITD degarder
|
CRBN(FLT3)-8 a highly potent FLT3 degrader by introducing gilteritinib into targeted protein degradation technology, potently degrades FLT3-ITD via UPS and inhibits the proliferation of FLT3-ITD mutant AML cells more effectively than gilteritinib. |
| PC-49392 |
UBX-382
BTK PROTAC
|
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM. |
| PC-49380 |
INY-06-061
ERK5 PROTAC
|
INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment). |
| PC-49367 |
dBRD4-BD1
BRD4 PROTAC
|
dBRD4-BD1 is a potent, selective degrader of BRD4 with DC50 of 280 nM, Dmax 77%. |
| PC-49352 |
AZ6421
ER PROTAC
|
AZ'6421 is a Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor, shows ER binding and ER degradation with IC50 and DC50 values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines. |
| PC-49328 |
HPP-9
BET PROTAC
|
HPP-9 is a potent BET bromodomain degrader that acts through a PROTAC mechanism, HPP-9 is a long-acting Hedgehog pathway inhibitor. |
| PC-49310 |
SJPYT-195
GSPT1 PROTAC, PXR molecular glue
|
SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein. |
