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首页-抗体药物偶连体和PROTACs-PROTAC-FHD-609
FHD-609

Chemical Structure : FHD-609

CAS No.: 2676211-64-4

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FHD-609 (FHD609, FHD 609)

货号: PC-20694Not For Human Use, Lab Use Only.

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.

规格 价格 库存 数量
2 mg ￥1980 In stock
5 mg ￥3280 In stock
10 mg ￥5280 In stock
25 mg ￥8980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.
FHD-609 is effective at inhibiting the growth of a subset of AML cell lines, induce changes and apoptosis in cell cycle.
FHD-609 exihibits potent anti-tumor efficacy in AML CDX and PDX models.

物理化学性质&存储条件

分子量 829.02
分子式 C47H56N8O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-(6-(7-((1-(4-(6-(azetidin-1-yl)-2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Claudia Dominici, et al. Mol Cancer Ther (2023) 22 (12_Supplement): A049.

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