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首页-抗体药物偶连体和PROTACs-PROTAC-BSJ-04-146
BSJ-04-146

Chemical Structure : BSJ-04-146

CAS No.: 2414478-45-6

BSJ-04-146 (FAK degrader BSJ-04-146)

货号: PC-20684Not For Human Use, Lab Use Only.

BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM.

规格 价格 库存 数量
2 mg ¥2880 In stock
5 mg ¥4880 In stock
10 mg ¥7880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM.

物理化学性质&存储条件

分子量 955.05
分子式 C50H57F3N8O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((2-((4-(1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide

参考文献

1. Eriko Koide, et al. Chembiochem. 2023 Apr 23;e202300141.

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