| Cat. No. |
Product Name |
Information |
| PC-27186 |
dIRF4-2
IRF4 PROTAC
|
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h). |
| PC-27164 |
RAD51 PROTAC G73
RAD51 PROTAC
|
RAD51 PROTAC G73 is an effective RAD51 PROTAC degrader with DC50 of 268 nM in PC-3 cells. |
| PC-27137 |
XYD113
GSPT1 degrader
|
XYD113 is a potent and highly selective, orally bioavailable CRBN-dependent GSPT1 molecular glue degrader, exerts potent antiproliferative activity against 22Rv1 cells with IC50 of 69 nM, induces complete degradation of GSPT1 at 111 nM. |
| PC-27120 |
SMD-6346
SMARCA2 PROTAC
|
SMD-6346 is a highly potent, selective and orally available SMARCA2 PROTAC degrader with DC50 of 3.3 nM and Dmax > 90%, shows much weaker activity against SMARCA4 (DC50 > 1000 nM, Dmax = 46%). |
| PC-27096 |
HDAC6 PROTAC 15
HDAC6 PROTAC
|
HDAC6 PROTAC 15 is a potent, selective HDAC6 degrader with pDC50 of 9.1 in bronchial epithelium cells, reduces α-tubulin hyperacetylation without affecting histone-3 acetylation. |
| PC-27030 |
dCBP-30
CBP/p300 degrader
|
dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300). |
| PC-26976 |
R4VPL3-1
RNF4 degrader
|
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells. |
| PC-26975 |
RNF4 PROTAC RD12
RNF4 degrader
|
RNF4 PROTAC degrader RD12 is an effective, selective RNF4 PROTAC degrader with DC50 of 4.16 uM in Huh7 cell line, degrades RNF4 via the ubiquitin-proteasome system and induces DNA damage and apoptosis. |
| PC-26928 |
XYD224
BRD9 degrader
|
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells. |
| PC-26926 |
M9101
Aurora A PROTAC
|
M9101 is a potent, selective and in vivo active Aurora A PROTAC degrader with DC50 value of 2.3 nM in MD-MBA-231 cells. |
| PC-26875 |
KTX-545
IRAK4 degrader
|
KTX-545 (KTX545) is a potent, selective IRAK4-targeting degrader with DC50 of 0.9 nM determined in in vitro assays with human monocytes. |
| PC-26832 |
dCDK9-010
P-TEFb degrader
|
dCDK9-010 is a highly efficient and selective positive transcription elongation factor b (P-TEFb) complex PROTAC degrader with DC50 of 0.5 uM in NCI-H226 cells, recruits the MDM2 E3 ligase to induce proteasome-dependent degradation of CDK9 and all cyclin T isoforms. |
