| Cat. No. |
Product Name |
Information |
| PC-23403 |
MS105
PTK6 PROTAC
|
MS105 (YX39-105) is a potent, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader, specifically and potently degrades PTK6 in a proteasome and VHL-dependent manner with DC50 of 21 nM and Dmax of 84% in MDA-MB-231/LM2-4 cells. |
| PC-23305 |
pan-KRAS degrader 4
pan-KRAS PROTAC
|
pan-KRAS degrader 4 is a potent, selective, reversible heterobifunctional pan-KRAS PROTAC degrader with Dmax50 of 17 nM in GP5d cells, efficiently degrades 13 of the 17 most prevalent KRAS mutant alleles and KRASWT with single-digit nanomolar potency. |
| PC-23276 |
DD205-291
HPK1 PROTAC
|
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM. |
| PC-23176 |
AK-1690
STAT6 PROTAC
|
AK-1690 is the first, potent and selective PROTAC STAT6 degrader with DC50 of 1 nM in MV4;11 cells, Dmax>95%. |
| PC-23155 |
ZLC491
CDK12/13 PROTAC
|
ZLC491 is a potent, selective, and orally bioavailable CDK12/13 PROTAC degrader with DC50 values of 32 and 28 nM, respectively, in TNBC MDA-MB-231 cells. |
| PC-23149 |
YJ1206
CDK12/13 PROTAC
|
YJ1206 is a selective, orally bioavailable CDK12/13 PROTAC degrader, shows potent degradation effects and inhibits VCaP cell viability (IC50=12.5 nM). |
| PC-23133 |
SMARCA2 PROTAC YD23
SMARCA2 PROTAC
|
SMARCA2 PROTAC YD23 is a potent and selective proteolysis targeting chimera (PROTAC) targeting SMARCA2 with DC50 of 64 nM in H1792 cells and Dmax of 88%. |
| PC-23063 |
BTX-1188
GSPT1 and IKZF1/3 PROTAC
|
Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells. |
| PC-22963 |
ENL degrader MS41
ENL PROTAC
|
MS41 is a potent and selective, VHL-recruiting ENL PROTAC degrader, induces robust ENL degradation in a variety of human leukemia cell lines with DC50 of 3.50, 2.84, 3.03, and 26.58 nM in MV4;11, SEMK2, Jurkat, and KASUMI1, respectively, Dmax>93%. |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22939 |
CW-3308
BRD9 PROTAC
|
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line. |
