| Cat. No. |
Product Name |
Information |
| PC-20693 |
KT-474
IRAK4 PROTAC
|
KT-474 (SAR444656, KYM-001) is a potent, selective, and orally bioavailable heterobifunctional IRAK4 PROTAC degrader with DC50 of 2 nM in OCI-Ly10 cells, IC50 of 41 nM. |
| PC-20684 |
BSJ-04-146
FAK PROTAC
|
BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM. |
| PC-20665 |
ARV-766
AR PROTAC
|
ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. |
| PC-20593 |
CFT1946
mutant BRAF PROTAC
|
CFT1946 (CFT-1946) is a potent, selective CRBN-based PROTAC degrader of mutant BRAF, selectively degrades BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations and the p61-BRAFV600E splice variant, but not WT BRAF and CRAF. |
| PC-20565 |
CP5V
Cdc20 PROTAC
|
CP5V (apcin-A-PEG5-VHL Ligand 1) is an efficient, selective Cdc20 PROTAC with DC50 of 1.6 uM in both MCF7 and MDA-MB-231 cells, induces mitotic inhibition and suppresses cancer cell proliferation. |
| PC-20560 |
NX-2127
BTK PROTAC
|
NX-2127 (NX2127) is a hetero-bifunctional, orally active PROTAC that induces the degradation of BTK and IKZF3 ubiquitination and proteasomal degradation in cells through recruitment of cereblon (CRBN). |
| PC-20466 |
BSJ-05-037
ITK PROTAC
|
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. |
| PC-20464 |
BI 1810284
SMARCA2 PROTAC
|
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4. |
| PC-20356 |
UNC8153
NSD2 PROTAC
|
UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark. |
| PC-20349 |
DU-14
PTP1B/TC-PTP PROTAC
|
DU-14 is a highly potent and selective small molecule degrader for both PTP1B and TC-PTP with DC50 values of 4.3 and 4.8 nM, respectively, in HEK293 cells after 16 hours treatment. |
| PC-20323 |
LL-K8-22
CDK8 degarder
|
LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins. |
| PC-20168 |
ZZ151
SOS1 PROTAC
|
ZZ151 (ZZ-151) is a highly potent and selective SOS1 degrader PROTAC with DC50 of 15.7 nM (Dmax=100%). |
