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首页-抗体药物偶连体和PROTACs-PROTAC-RDN8011
RDN8011

Chemical Structure : RDN8011

CAS No.:

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RDN8011

货号: PC-24058Not For Human Use, Lab Use Only.

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RDN8011 is a potent, selective first-in-class PROTAC degrader of KDM4 with DC50 of 37-50 nM for KDM4A/KDM4B/KDM4C in in KYSE-150 cells, while sparing KDM4D.
RDN8011 acts KDM4A degradation mediated by the ubiquitin-proteasome system (UPS).
RDN8011 (0-10 uM) upregulates H3K36 methylation and induces cell cycle arrest and apoptosis in KYSE-150 cells.

物理化学性质&存储条件

分子量 1002.29
分子式 C56H71N7O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Rao D, et al. Eur J Med Chem. 2025 Feb 19;288:117410.

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