Epaldeudomide (KPG-818) | IKZF1/3 molecular glue | Probechem Biochemicals

Chemical Structure : Epaldeudomide

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Epaldeudomide (KPG-818, KPG818)

货号: PC-24133Not For Human Use, Lab Use Only.

Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects.

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生物&药学活性

Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects.

物理化学性质&存储条件

分子量	468.50
分子式	C25H25DFN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-Piperidinedione-3-d, 3-[4-[[2-fluoro-4-(4-morpholinylmethyl)phenyl]methoxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, (3S)-

参考文献

1. Patent WO2016065980 A1.

Epaldeudomide (KPG-818, KPG818)

生物&药学活性

物理化学性质&存储条件

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Epaldeudomide (KPG-818, KPG818)

生物&药学活性

物理化学性质&存储条件

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