DEG-77 | IKZF2/CK1α degarder | Probechem Biochemicals

Chemical Structure : DEG-77

CAS No.:

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DEG-77 (Dual IKZF2/CK1α degarder DEG-77)

货号: PC-23963Not For Human Use, Lab Use Only.

DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively.
DEG-77 shows increased selectivity against IKZF2 (DC50 = 15.3 nM) and CK1α (DC50 = 10 nM) over other known neosubstrates (GSPT1, IKZF1, IKZF3).
DEG-77 reduced abundance of HOXA9 and c-MYC in MOLM-13 cells.
DEG-77 treatment resulting in increased apoptosis, myeloid differentiation, and induction of the TP53 pathway, and comparable preferential sensitivity to leukemia versus healthy cells.
DEG-77 has better efficacy and can block leukemic stem cell activity.

物理化学性质&存储条件

分子量	447.45
分子式	C24H21N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)-8-methoxy-2H-chromene-3-carboxamide

参考文献

1. Park SM, et al. Cancer Cell. 2023 Apr 10;41(4):726-739.e11.

DEG-77 (Dual IKZF2/CK1α degarder DEG-77)

生物&药学活性

物理化学性质&存储条件

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DEG-77 (Dual IKZF2/CK1α degarder DEG-77)

生物&药学活性

物理化学性质&存储条件

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