KT-333 | STAT3 degrader | Probechem Biochemicals

Chemical Structure : KT-333

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KT-333 (KT333)

货号: PC-24047Not For Human Use, Lab Use Only.

KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines.

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生物&药学活性

KT-333 (KT333) is a potent, highly specific potent heterobifunctional PROTAC degrader of STAT3 with DC50 of 2.5 -11.8 nM in anaplastic T cell lymphoma (ALCL) lines.
KT-333 exhibits selective degradation of STAT3 over nearly 9000 proteins, including other STAT family members.
KT-333 treatment led to rapid apoptosis in tumor cells expressing NPM-ALK fusion oncoproteins.
KT-333 induces a significant reduction in STAT3 and MCL1 protein levels within two weeks of treatment in a cell derived xenograft model of Ven-res AML.

物理化学性质&存储条件

分子量	1257.79
分子式	C60H74ClN10O14PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(((5S,8S,10aR)-3-Acetyl-8-(((S)-5-amino-1-(2-chloro-3-(4-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic acid

参考文献

1. Chakraborty S, et al. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.599788.

2. Phillip CC Liu, et al. Blood (2021) 138 (Supplement 1): 1865.

KT-333 (KT333)

生物&药学活性

物理化学性质&存储条件

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KT-333 (KT333)

生物&药学活性

物理化学性质&存储条件

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