| Cat. No. |
Product Name |
Information |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-26139 |
KTX-951
IRAK4 PROTAC
|
KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways. |
| PC-26138 |
KTX-582
IRAK4 PROTAC
|
KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model. |
| PC-26133 |
GDCNF-11
GPX4 degrader
|
GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM. |
| PC-26131 |
GDAz-3
GPX4 degrader
|
GDAz-3 is a potent GPX4-targeting HSP70-PROTAC, potently and rapidly eliminates GPX4 in HT1080 cells (DC50=0.13 uM), thereby triggering ferroptosis with high selectivity. |
| PC-26015 |
CCT400028
Aurora A PROTAC
|
CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling. |
