| Cat. No. |
Product Name |
Information |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
| PC-25851 |
D16-M1P2
PKMYT1 PROTAC
|
D16-M1P2 is a potent, highly specific, bifunctional PKMYT1-targeting PROTAC degrader with DC50 of 0.7 nM and Dmax of 90% in HCC1569 cells. |
| PC-25840 |
GSK3 degrader KH1
GSK3 PROTAC
|
GSK3 degrader KH1 is a potent, CNS in vivo active GSK3 PROTAC degrader with DC50 of 1.4 nM in HEK293 cells, induces almost complete GSK3α and GSK3β degradation at 10 nM in HEK293 cells (2 h). |
| PC-25828 |
KG-FP-003
TEAD PROTAC
|
KG-FP-003 is a potent, selective, and durable TEAD PROTAC degrader with biochemicals binding IC50 of 591 nM for CRBN, degrades all TEAD isoforms in NCI-H1299 cells (TEAD1, DC50= 6 nM, TEAD2 DC50= 68 nM, TEAD3 DC50 =12, TEAD4 DC50= 7 nM). |
| PC-25827 |
BCL6-760
BCL6 degrader
|
BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively. |
| PC-25824 |
DDO3602
PARP1 HSPTAC
|
DDO3602 is a potent, effective small molecule HSP90-mediated proteolysis-targeting chimera (HSPTAC) degrader of PARP1 with DC50 of 490.3 nM in MCF-7 cells, induces PARP1 degradation through a multi-E3 ubiquitin ligase-mediated degradation pathway. |
| PC-25762 |
p53 Y220C DUBTAC A1
p53 Y220C DUBTAC
|
p53 Y220C DUBTAC A1 is a bifunctional small molecule p53 Y220C-specific deubiquitinase-targeting chimera (DUBTAC) recruiting both p53 Y220C and the deubiquitinase OTUB1, effectively reactivates and deubiquitinates mutant p53 Y220C in vitro and in vivo. |
| PC-25742 |
WZS0347
MITF PROTAC
|
WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells. |
| PC-25737 |
OUN20985
CRBN degrader
|
Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN. |
| PC-25736 |
MRT-31619
CRBN degrader
|
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation. |
| PC-25719 |
BCL6 PROTAC A19
BCL6 PROTAC
|
BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells. |
| PC-25704 |
LD5097
RIPK1 PROTAC
|
LD5097 is a potent, selective RIPK1 PROTAC degrader with DC50 of 0.7 nM in Jurkat cells, Dmax=96% (24h). |
