| Cat. No. |
Product Name |
Information |
| PC-22767 |
KT-413
IRAK4 PROTAC
|
KT-413 is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells. |
| PC-22750 |
BSJ-5-63
CDK12/7/9 degrader
|
BSJ-5-63 is a potent, triple degrader targeting cyclin-dependent kinases (CDKs) CDK12, CDK7, and CDK9, downregulates HRR genes and inhibits AR signaling. |
| PC-22749 |
SMART1
Smurf1 PROTAC degrader
|
SMART1 (Smurf1 PROTAC degrader) is a potent, highly selective degrader of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1) with DC50 of 1-5 nM in HT29 and PANC-1 cells, Dmax of 86%. |
| PC-22720 |
BTK-PROTAC C13
BTK PROTAC
|
BTK-PROTAC C13 is a highly potent, selective and orally bioavailable BTK PROTAC degrader with DC50 of 5.8 nM in Mino cells, Dmax=96%, degrades C481 and T316-mutated BTK proteins |
| PC-22688 |
CP134
DYRK2 PROTAC
|
CP134 is a potent, selective PROTAC degrader of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with DC50 of 1.6 uM in MM231 and 3.3 uM in HeLa, respectively. |
| PC-22665 |
JWZ-5-13
CDK7 degrader
|
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner. |
| PC-22653 |
SJF620
BTK PROTAC
|
SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%). |
| PC-22647 |
SJ11646
LCK PROTAC
|
SJ11646 is a potent, dasatinib-based, cereblon-mediated LCK PROTAC degrader with DC50 of 0.00838 pM in in KOPT-K1 T-ALL cells, cytotoxic IC50 of 0.083pM. |
| PC-22646 |
SJ45566
LCK PROTAC
|
SJ45566 is a potent, selective and orally active dasatinib-based LCK PROTAC degrader with DC50 of 1.21 nM (Dmax 98%) in KOPT-K1 cells. |
| PC-22590 |
UNC10088
NSD2 degrader
|
UNC10088 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22589 |
UNC8732 TFA
NSD2 degrader
|
UNC8732 TFA is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22588 |
UNC8732
NSD2 degrader
|
UNC8732 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
