| Cat. No. |
Product Name |
Information |
| PC-25906 |
G6374
IRE1 PROTAC
|
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells. |
| PC-25892 |
CDK6 PROTAC 48a
CDK6 PROTAC
|
CDK6 PROTAC 48a is a potent, selective, KLHDC2-mediated CDK6 PROTAC degrader with DC50 of 37 nM in MOLM-14 cells, selectively degrades CDK6 among 8642 proteins and within the CDK family. |
| PC-25887 |
PLK4 PROTAC SP27
PLK4 PROTAC
|
PLK4 PROTAC SP27 is a potent, selective PLK4 proteolysis targeting chimera (PROTAC) degrader with binding IC50 of 8.4 nM for PLK4, DC50 of 19.5 nM in MCF-7 cells. |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
| PC-25871 |
LAG-3 PROTAC-1
LAG-3 PROTAC
|
LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h). |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
| PC-25851 |
D16-M1P2
PKMYT1 PROTAC
|
D16-M1P2 is a potent, highly specific, bifunctional PKMYT1-targeting PROTAC degrader with DC50 of 0.7 nM and Dmax of 90% in HCC1569 cells. |
| PC-25840 |
GSK3 degrader KH1
GSK3 PROTAC
|
GSK3 degrader KH1 is a potent, CNS in vivo active GSK3 PROTAC degrader with DC50 of 1.4 nM in HEK293 cells, induces almost complete GSK3α and GSK3β degradation at 10 nM in HEK293 cells (2 h). |
| PC-25828 |
KG-FP-003
TEAD PROTAC
|
KG-FP-003 is a potent, selective, and durable TEAD PROTAC degrader with biochemicals binding IC50 of 591 nM for CRBN, degrades all TEAD isoforms in NCI-H1299 cells (TEAD1, DC50= 6 nM, TEAD2 DC50= 68 nM, TEAD3 DC50 =12, TEAD4 DC50= 7 nM). |
| PC-25827 |
BCL6-760
BCL6 degrader
|
BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively. |
| PC-25824 |
DDO3602
PARP1 HSPTAC
|
DDO3602 is a potent, effective small molecule HSP90-mediated proteolysis-targeting chimera (HSPTAC) degrader of PARP1 with DC50 of 490.3 nM in MCF-7 cells, induces PARP1 degradation through a multi-E3 ubiquitin ligase-mediated degradation pathway. |
| PC-25762 |
p53 Y220C DUBTAC A1
p53 Y220C DUBTAC
|
p53 Y220C DUBTAC A1 is a bifunctional small molecule p53 Y220C-specific deubiquitinase-targeting chimera (DUBTAC) recruiting both p53 Y220C and the deubiquitinase OTUB1, effectively reactivates and deubiquitinates mutant p53 Y220C in vitro and in vivo. |
