GSK983 |CAS 2984100-87-8 Probechem Biochemicals

Chemical Structure : GSK983

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GSK983 (GSK-983;GSK 983)

货号: PC-35668Not For Human Use, Lab Use Only.

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.

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生物&药学活性

GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively
GSK983 also potently induces robust and concentration-dependent degradation of PCAF and GCN5 in both macrophages and monocyte-derived dendritic cells (DCs).
GSK983 potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells.

物理化学性质&存储条件

分子量	895.856
分子式	C45H51BrN8O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-((5-bromo-1-methyl-6-oxo-1,6-dihydropyridazin-4-yl)amino)-1-methylpiperidin-3-yl)-N-(3-((4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)propyl)phenyl)(methyl)amino)propyl)-N-methylbenzamide

参考文献

1. Bassi ZI, et al. ACS Chem Biol. 2018 Oct 19;13(10):2862-2867.

GSK983 (GSK-983;GSK 983)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK983 (GSK-983;GSK 983)

生物&药学活性

物理化学性质&存储条件

参考文献

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