HDAC6 degrader 9c |CAS: 2235382-05-3 Probechem Biochemicals

Chemical Structure : HDAC6 degrader 9c

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HDAC6 degrader 9c (dHDAC6 9c)

货号: PC-35282Not For Human Use, Lab Use Only.

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.

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生物&药学活性

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
HDAC6 degrader 9c causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM.
HDAC6 degrader 9c shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.

物理化学性质&存储条件

分子量	775.82
分子式	C37H45N9O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-8-(2-(4-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

参考文献

1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132.

HDAC6 degrader 9c (dHDAC6 9c)

生物&药学活性

物理化学性质&存储条件

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HDAC6 degrader 9c (dHDAC6 9c)

生物&药学活性

物理化学性质&存储条件

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