BTK PROTAC 10

Chemical Structure : BTK PROTAC 10

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货号: PC-35425Not For Human Use, Lab Use Only.

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.

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生物&药学活性

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.
BTK PROTAC 10 can successfully delivered to tissues and can specifically degrade BTK in vivo, in a dose-dependent and tissue-biased manner by s.c. administration.

物理化学性质&存储条件

分子量	976.989
分子式	C47H54F2N8O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	17-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1Hisoindol-4-yl]amino}-3,6,9,12,15-pentaoxaheptadec-1-yl(3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

参考文献

1. Zorba A, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201803662.

BTK PROTAC 10

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物理化学性质&存储条件

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BTK PROTAC 10

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