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首页-抗体药物偶连体和PROTACs-PROTAC-SJF-8240
SJF-8240

Chemical Structure : SJF-8240

CAS No.: 2230821-68-6

SJF-8240 (SJF8240, Foretinib-Based PROTAC 7)

货号: PC-35356Not For Human Use, Lab Use Only.

SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.

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5 mg ¥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.

物理化学性质&存储条件

分子量 1106.253
分子式 C58H65F2N7O11S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic

参考文献

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.

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