| Cat. No. |
Product Name |
Information |
| PC-35884 |
DD-03-171
BTK degrader
|
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3. |
| PC-35882 |
VZ185
BRD7/BRD9 PROTAC
|
VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively. |
| PC-35859 |
FKBP12 PROTAC dTAG-13
FKBP12 degrader
|
FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells. |
| PC-35858 |
FKBP12 PROTAC dTAG-7
FKBP12 degrader
|
FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells. |
| PC-35762 |
A1874
BRD4 PROTAC
|
A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells). |
| PC-35717 |
BCL6 PROTAC 15
BCL6 PROTAC
|
BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response.. |
| PC-35668 |
GSK983
PCAF/GCN5 PROTAC
|
GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively. |
| PC-35667 |
GSK699
PCAF/GCN5 PROTAC
|
GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells. |
| PC-35425 |
BTK PROTAC 10
BTK PROTAC
|
BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells. |
| PC-35424 |
BTK PROTAC 9
BTK PROTAC
|
BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK. |
| PC-35399 |
QCA570
BET PROTAC
|
QCA570 is a highly potent efficacious BET degrader (PROTAC) with IC50 of 10 nM (BRD4 BD1). |
| PC-35357 |
Gefitinib-based PROTAC 3
EGFR PROTAC
|
Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R). |
