| Cat. No. |
Product Name |
Information |
| PC-35667 |
GSK699
PCAF/GCN5 PROTAC
|
GSK699 (GSK-699) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells. |
| PC-35425 |
BTK PROTAC 10
BTK PROTAC
|
BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells. |
| PC-35424 |
BTK PROTAC 9
BTK PROTAC
|
BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK. |
| PC-35399 |
QCA570
BET PROTAC
|
QCA570 is a highly potent efficacious BET degrader (PROTAC) with IC50 of 10 nM (BRD4 BD1). |
| PC-35357 |
Gefitinib-based PROTAC 3
EGFR PROTAC
|
Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R). |
| PC-35356 |
SJF-8240
c-Met PROTAC
|
SJF-8240 (Foretinib-Based PROTAC 7) is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells. |
| PC-35351 |
BRD4 degrader AT1
BRD4 PROTAC
|
BRD4 degrader AT1 is a highly selective BRD4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3. |
| PC-35282 |
HDAC6 degrader 9c
HDAC6 degrader
|
HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand. |
| PC-35215 |
dBET57
BRD4 BD1 PROTAC
|
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.. |
| PC-35214 |
dBET23
BRD4 PROTAC
|
dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays. |
| PC-35213 |
MT-802
BTK PROTAC
|
MT-802 (MT802) is a potent BTK PROTAC degrader that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM). |
| PC-35204 |
ZXH-3-26
BRD4 BD1 PROTAC
|
ZXH-3-26 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), shows activity exclusively on the BRD4 BD1 (DC50/5h=5 nM) and spares degradation of BRD2 or BRD3 in cellular degradation assays. |
