MS6105 | LDHA/B PROTAC | Probechem Biochemicals

Chemical Structure : MS6105

CAS No.: 2891709-58-1

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MS6105 (MS 6105)

货号: PC-49594Not For Human Use, Lab Use Only.

MS6105 is the first lactate dehydrogenase (LDH) proteolysis targeting chimera (PROTAC) degrader, degrads both LDHA and LDHB significantly with DC50 of 38 and 74 nM in PANC-1 cells, respectively.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

MS6105 is the first lactate dehydrogenase (LDH) proteolysis targeting chimera (PROTAC) degrader, degrads both LDHA and LDHB significantly with DC50 of 38 and 74 nM in PANC-1 cells, respectively.
MS6105 significantly more potent than the parent LDH inhibitor in suppressing the growth of both quasi-mesenchymal state and epithelial state pancreatic cancer cell lines.
MS6105 is bioavailable in mice through intraperitoneal injection.

物理化学性质&存储条件

分子量	1228.597
分子式	C65H81N9O9S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic Acid

参考文献

1. Ning Sun, et al. J Med Chem. 2023 Jan 12;66(1):596-610.

MS6105 (MS 6105)

生物&药学活性

物理化学性质&存储条件

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MS6105 (MS 6105)

生物&药学活性

物理化学性质&存储条件

参考文献

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