| Cat. No. |
Product Name |
Information |
| PC-22486 |
XYD129
CBP/p300 degrader
|
XYD129 is a highly potent and selective CBP/p300 degrader with IC50 of 21/30 nM, effectively degrades CBP/p300 proteins and exhibits potent inhibition of growth in acute leukemia cell lines (MOLM-16, IC50=7.4 nM). |
| PC-22441 |
ARM165
PIK3CG/p110γ degrader
|
ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML. |
| PC-22413 |
AN2
mHTT degrader
|
AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
| PC-22412 |
AN1
mHTT degrader
|
AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT. |
| PC-22411 |
HL435
BRD4 degrader
|
HL435 is a potent, alkenyl oxindole-based heterobifunctional BRD4 degrader PROTAC with DC50 values of 11.9 and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. |
| PC-22394 |
MS140
CDK4/6 degrader
|
MS140 is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels. |
| PC-22393 |
WEE1/CK1α degrader 2
WEE1/CK1α degrader
|
WEE1/CK1α degrader 2 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.6/1.5 nM, respectively, Emax >98%. |
| PC-22392 |
WEE1/CK1α degrader 1
WEE1/CK1α degrader
|
WEE1/CK1α degrader 1 is a highly potent WEE1/CK1α molecular glue degrader with DC50 of 1.1/3.1 nM, respectively. |
| PC-22391 |
WEE1 degrader 2
WEE1 degrader
|
WEE1 degrader 2 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 140 nM and Emax of 85%, does not degrade CK1α. |
| PC-22390 |
WEE1 degrader 1
WEE1 degrader
|
WEE1 degrader 1 is a potent, selective CRBN-dependent WEE1 molecular glue degrader with DC50 of 91 nM, does not degrade CK1α. |
| PC-22339 |
LLC355
DDR1 degrader
|
LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion. |
| PC-22314 |
LC-MI-3
IRAK4 degrader
|
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%. |
