| Cat. No. |
Product Name |
Information |
| PC-22963 |
ENL degrader MS41
ENL PROTAC
|
MS41 is a potent and selective, VHL-recruiting ENL PROTAC degrader, induces robust ENL degradation in a variety of human leukemia cell lines with DC50 of 3.50, 2.84, 3.03, and 26.58 nM in MV4;11, SEMK2, Jurkat, and KASUMI1, respectively, Dmax>93%. |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22940 |
CBPD-268
CBP/p300 PROTAC
|
CBPD-268 is a potent, effective, and orally efficacious PROTAC degrader of CBP/p300 proteins DC50 of 0.5 nM against CBP and DC50 of 0.8 nM against p300 and Dmax of 100% against both proteins in the HiBit assays. |
| PC-22939 |
CW-3308
BRD9 PROTAC
|
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line. |
| PC-22938 |
YZ167
HDAC6 PROTAC
|
YZ1678 is a potent, selective HDAC6 PROTAC degrader with DC50 of 1.94 nM in MM.1S cells. |
| PC-22884 |
CST967
USP7 PROTAC
|
CST967 is a potent selective USP7 PROTAC degrader with DC50 of 17 nM, Dmax of 84% in MM.1S cells. |
| PC-22861 |
BTK PROTAC degrader 3
BTK PROTAC
|
BTK PROTAC degrader 3 is a potent BTK degrader with DC50 value of 10.9 nM in Mino cells, shows potential for B-cell malignancies, including chronic lymphoid malignancies. |
| PC-22852 |
MGP-39
MELK PROTAC
|
MGP-39 is a first-in-class PROTAC degrader targeting maternal embryonic leucine zipper kinase (MELK), induced potent and rapid degradation of MELK in Burkitt lymphoma cell (Dmax=91.6%), and IC50 of 1.8 uM for RAMOS cell line. |
| PC-22824 |
AZ3137
AR degrader
|
AZ3137 (AZ′3137) a potent, selective, orally bioavailable androgen aeceptor (AR) PROTAC degrader with DC50 of 22 nM and 92 nM for LNCaP cells expressing WT AR and AR T878A/L702H respectively. |
| PC-22823 |
MMH2
BRD4 degrader
|
MMH2 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4. |
| PC-22822 |
MMH1
BRD4 degrader
|
MMH1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4. |
