DD-03-171 | 2366132-45-6 Probechem Biochemicals

Chemical Structure : DD-03-171

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DD-03-171 (BTK PROTAC degrader)

货号: PC-35884Not For Human Use, Lab Use Only.

DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.

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生物&药学活性

DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.
DD-03-171 also displays efficacy against patient-derived xenografts in vivo.

物理化学性质&存储条件

分子量	991.163
分子式	C55H62N10O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(tert-butyl)-N-(3-(6-((4-(4-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)hexyl)piperazine-1-carbonyl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)benzamide

参考文献

1. Dobrovolsky D, et al. Blood. 2018 Dec 13. pii: blood-2018-07-862953. doi: 10.1182/blood-2018-07-862953.

DD-03-171 (BTK PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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DD-03-171 (BTK PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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