FKBP12 PROTAC dTAG-7 |CAS:2064175-32-0 Probechem Biochemicals

Chemical Structure : FKBP12 PROTAC dTAG-7

CAS No.: 2064175-32-0

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FKBP12 PROTAC dTAG-7 (dTAG-7)

货号: PC-35858Not For Human Use, Lab Use Only.

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.

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2 mg	￥2180	In stock
5 mg	￥3880	In stock
10 mg	￥5980	In stock
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50 mg		Get quote

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生物&药学活性

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells.
dTAG-7 causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras.

物理化学性质&存储条件

分子量	1210.341
分子式	C63H79N5O19
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

参考文献

1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441.

FKBP12 PROTAC dTAG-7 (dTAG-7)

生物&药学活性

物理化学性质&存储条件

参考文献

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FKBP12 PROTAC dTAG-7 (dTAG-7)

生物&药学活性

物理化学性质&存储条件

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