VZ185 | BRD7/BRD9 PROTAC | Probechem Biochemicals

Chemical Structure : VZ185

CAS No.: 2306193-61-1

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VZ185 (VZ-185, VZ 185)

货号: PC-35882Not For Human Use, Lab Use Only.

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥2980	In stock
10 mg	￥4680	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.
VZ185 induces strong and rapid degradation of of BRD9, BRD7 in a time- and dose-dependent manner after treatment of RI-1 cells, also shows a DC50 between 2-8 nM for BRD9 in a panel of other human cancer cell lines (EOL-1, A-204).

物理化学性质&存储条件

分子量	995.225
分子式	C53H67FN8O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-N-(2-((5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

参考文献

1. Zoppi V, et al. J Med Chem. 2018 Dec 12. doi: 10.1021/acs.jmedchem.8b01413.

VZ185 (VZ-185, VZ 185)

生物&药学活性

物理化学性质&存储条件

参考文献

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VZ185 (VZ-185, VZ 185)

生物&药学活性

物理化学性质&存储条件

参考文献

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