| Cat. No. |
Product Name |
Information |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells. |
| PC-21642 |
DBr-1
DCAF1-BRD9 PROTAC
|
DBr-1 (DCAF1-BRD9 PROTAC) is a potent, selective DCAF1-BRD9 PROTAC (DC50=90 nM, HEK293) by coupling the BRD9 bromodomain binder BI-9564 via a piperidine and aliphatic carbon linker to the piperazine of DCAF1 binder. |
| PC-21567 |
BGB-16673
BTK PROTAC
|
Catadegbrutinib (BGB-16673) is an orally available heterobifunctional BTK PROTAC degrader that binds to BTK and E3 ligase, degrades wildtype BTK and multiple mutant forms via ubiquitination. |
| PC-21533 |
KH-103
GR PROTAC
|
KH-103 is a highly potent, catalytically-driven glucocorticoid receptor (GR) PROTAC degrader, demonstrate excellent performance in passively preventing ligand-induced gene expression activation in the absence of partial agonistic transcriptional triggering and crosstalk inhibition. |
| PC-21507 |
MS132
WDR5 PROTAC
|
MS132 is a highly potent and selective VHL-recruiting WDR5 PROTAC degrader with DC50 of 92 nM in MIA PaCa-2 cells. |
| PC-21468 |
PIK5-12d
PIKfyve PROTAC
|
PIK5-12d is a highly potent, selective, first-in-class PIKfyve PROTAC degrader, potently degrades PIKfyve protein with DC50 value of 1.48 nM and Dmax value of 97.7% in prostate cancer VCaP cells. |
| PC-21323 |
NX-5948
BTK PROTAC
|
NX‑5948 (NX5948) is a potent, selective and brain-penetrant degrader of BTK with DC50 of <1 nM in lymphoma cell lines and peripheral blood mononuclear cells (PBMCs). |
| PC-21123 |
BWA-522
AR-NTD PROTAC
|
BWA-522 is a potent, orally bioavailable PROTAC degrader of the androgen receptor N-terminal domain (AR-NTD), induces AR-FL or AR-V7 protein degradationwith DC50 of 0.73 μM (AR-FL) and 0.67 μM (AR-V7) in VCaP cells. |
| PC-21118 |
HDAC3 PROTAC P7
HDAC3 PROTAC
|
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%). |
