| Cat. No. |
Product Name |
Information |
| PC-26588 |
TNG961
HBS1L degrader
|
TNG961 (TNG-961) is a potent, selective and oral CRBN-dependent HBS1L (GSPT3) molecular glue degrader with DC50 of 7 nM and Dmax of 98%, does not affect closely related GSPT1 protein, disrupts the HBS1L/PELO complex. |
| PC-26498 |
Cyclin D1 degrader MS28
Cyclin D1 degrader
|
Cyclin D1 degrader MS28 (XY028-133) is a potent, selective and first-in-class PROTAC degrader of cyclin D1 through recruiting the CDK4/6-cyclin D1 complex to VHL E3 ligase, effectively degrades cyclin D1 in Calu-1 cells with DC50 of 950 nM and Dmax of 90% (8 h). |
| PC-26447 |
SD-965
STAT3 PROTAC
|
SD-965 is a potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 0.14 uM and Dmax = 85%, inhibits cell growth of MOLM-16 leukemia cell line with IC50 of 1.3 nM. |
| PC-26369 |
HD-TAC7
HDAC3 PROTAC
|
HD-TAC7 is a potent, selective Cereblon-dependent HDAC3 PROTAC degrader with DC50 of 0.32 uM in RAW 264.7 cells. |
| PC-26132 |
dGPX4
GPX4 PROTAC
|
dGPX4 is a potent GPX4 PROTAC degrader, depletes GPX4 via proteasomal protein degradation, induces cell-selective ferroptosis by targeting cancer cell microenvironment. |
| PC-25906 |
G6374
IRE1 PROTAC
|
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells. |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
| PC-25851 |
D16-M1P2
PKMYT1 PROTAC
|
D16-M1P2 is a potent, highly specific, bifunctional PKMYT1-targeting PROTAC degrader with DC50 of 0.7 nM and Dmax of 90% in HCC1569 cells. |
| PC-25840 |
GSK3 degrader KH1
GSK3 PROTAC
|
GSK3 degrader KH1 is a potent, CNS in vivo active GSK3 PROTAC degrader with DC50 of 1.4 nM in HEK293 cells, induces almost complete GSK3α and GSK3β degradation at 10 nM in HEK293 cells (2 h). |
| PC-25824 |
DDO3602
PARP1 HSPTAC
|
DDO3602 is a potent, effective small molecule HSP90-mediated proteolysis-targeting chimera (HSPTAC) degrader of PARP1 with DC50 of 490.3 nM in MCF-7 cells, induces PARP1 degradation through a multi-E3 ubiquitin ligase-mediated degradation pathway. |
| PC-25679 |
G-6599
SMARCA2/A4 degrader
|
G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22. |
| PC-25674 |
AMPTX1
BRD9 degrader
|
AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h). |
